Page 4, Conclusion: the assertion concerning the ethics of the two Phase 3 clinical trials needs toning down. This paper by Amrhein et al. Chamberlain and Szöcs present the taxize R package, a set of functions that provides interfaces to several web tools and databases, and simplifies the process of checking, updating, correcting and manipulating taxon names for researchers working with ecological/biological data. Most of these have human orthologs. They overstate some difficulties of peer-review (No-one looks at every data value? I will make some more concrete comments below. The email address should be the one you originally registered with F1000. factor and covariate Tab. After placing your order by submitting your assignment instructions, make payments. In the first it remains unchanged at 1/2 where it was set. One can think of Pr(x = 1) as the population-level proportion of twins that are identical for a mother like the one being considered. Minor points to consider in subsequent versions: The authors describe their attempt to reproduce a study in which it was claimed that mild acid treatment was sufficient to reprogramme postnatal splenocytes from a mouse expressing GFP in the oct4 locus to pluripotent stem cells. Note to self: You are no longer allowed to bring books this good on family road trips. This study, which was originally designed to identify axonal chemorepellents, actually provided a previously unknown role for H1, as well as other novel and thought provoking results. With modifications addressing the detailed comments below and better recognizing the complexity of the current data publication landscape, this will be a worthwhile review paper. Deyan Sudjic, Director of the Design Museum, decodes the underlying forces that shape the urban spaces around us, from their buildings to their names, from the power of crowds to why being a Londoner, New Yorker or Muscovite can offer a ... It reminds me of Ocean's Eleven meets The Italian Job, but set in Mordor after Sauron has ruled for 1000 years or so. With my J.D. Even under the most pressing deadlines, our editorial team can work with you to prepare and distribute your news quickly and accurately. In their response to my previous comments, the authors have clarified that only the data from the “Experimental phase” were used to calculate prediction accuracy. And then, even after an eight-mile hike in the desert when you, Note to self: You are no longer allowed to bring books this good on family road trips. This is an opinion piece, yet I see little opinion. Some of world-building made the start a little slow and the battle scenes were sometimes long, and given how allomancers fight, they sometimes seemed very much like battles that had been fought in previous pages. We surmise that results obtained from the experiments described in this section cannot serve to understand the role of INaL in arrhythmogenesis. Your ethics texts make it sound like you can snap your fingers and I will jump into your bed. The authors take a rather narrow view of data publication, which I think hinders their analyses. The conceptual leap here is that progress in genetics is driven by phenotype, and this approach involving a yeast with no spine or muscles to atrophy is nevertheless and N-dimensional detector of phenotype. Depends. To do so, they can enter as random factor the interaction Science 340(6137): 1177-1178. Mean litter depth graph (Figure 2) and accompanying text reports the means and sd but no post-hoc comparison test (e.g. More often there are teams working together to develop experiments, sampling protocols, algorithms, etc. Start by marking “Mistborn: The Final Empire (Mistborn, #1)” as Want to Read: Error rating book. Is it a consequence of a time-dependent shift of the voltage dependence of activation/inactivation? Are they identical (which I describe as the state x = 1) or fraternal twins (x = 0)? I believe this is what happened here and thus I think this experiment serves as a very good demonstration for the pitfalls of applying such analysis without sanity checks. With more significant modification where the authors dig deeper into the complexities and controversies and truly grapple with their implications to suggest a way forward, this could be a very influential paper. In the ‘mynames’ definition you include ‘Helianthus annuus’ in the character vector but the output shown suggests that the submitted name was ‘Helianthus annus’ (1 “u”) in rows with rownames 9 and 10 in the output shown. Fortuitously, as sometimes happens, the authors had a pleasant surprise: their results set some old dogmas on their respective ears and opened up new avenues of approach for studying the role of histones in self-amplification of neurodegenerative cycles. But given that there appears to be errors in both Efron (2013b) and the paper under review, I am sorry to say that my review might actually be longer than the article by Efron (2013a), the primary focus of the critique, and the critique itself. In more detail, Gilthorpe and colleagues provide novel experimental data that demonstrate a new role for a specific histone protein—the linker histone, H1—in neurodegeneration. I'm literally so fucking bitter and salty that I didn't enjoy this hyped as fuck book that no one has ever written a single negative review for. definition? Here the authors demonstrated that ventricular myocytes derived from hiPS generate beautiful action potentials that can be recorded with this automated equipment. I liked the characters, including a strong female heroine, Vin (her trust issues and ultimately her heroism), and the world-building that was there from beginning to end. In order to make more precise mechanistic assumptions, the authors performed an elegant estimation of current variance (σ2) and macroscopic current (I) following the procedure described more than 30 years ago by Van Driessche and Lindemann 1. I see three main problems with the statistics that could have led to potentially wrong results and, thus, to completely misleading conclusions. Let y be the data, with y = 1 to indicate the twins are the same gender. In this, the Dark Lord is already set in place as the status quo and the heroes have to motivate others to want a change.....Yet there is a noble class of The Lord Ruler's flunkies who will need to be scammed and robbed along the way, to finance this big revolt.....I love. Found insideThis new edition of the practice guidelines on psychiatric evaluation for adults is the first set of the APA's guidelines developed under the new guideline development process. Regardless of the answer to this rhetorical question, “checking” the results with frequentist methods doesn’t give any more insight than using uninformative priors (in this case). Can this problem be overcome? However, the data point (the twins have the same gender) is entirely relevant to the question about the state of this particular set of twins. Andrew Ng from Coursera and Chief Scientist at Baidu Research formally founded Google Brain that eventually resulted in the productization of deep learning technologies across a large number of Google services.. The F1000Research website uses cookies. Anything could be a feature but typically this might be the different EEG channels or fMRI voxels etc. Why are there different models and which approach is better for different situations? No one is violating logic – they are merely expressing ignorance by specifying equal probabilities to all states of nature. I think this paper excellent and is an important addition to the literature. The traces shown suggested that there was not alternation in the action potential duration. conclusions far too permissive. One way to remove these doubts could be to stratify the analyses by the length of sequences of identical symbols. It predicts that genetic variability for these traits exist within the populations. (NSICD, instead of NSIDC), In the discussion of “Data independent of any paper” it is worth noting that there may often be linkages between these data and myriad papers. criticizes a paper by Bradley Efron that discusses Bayesian statistics (Efron, 2013a), focusing on a particular example that was also discussed in Efron (2013b). The stimulus labels were assigned as ON or OFF for each sample. My suggestions are essentially that they extend the data set they are working with to ensure that their analysis is both rigorous and generalisable, an re-consider the analytical frame they use. While the revised methods section provides more detail now, it still is unclear about exactly what data were used. It is not stated if the dimensionality was reduced using the eigenvalues. Now we know that Pr(y = 1 | x = 1) = 1; twins must be the same gender if they are identical. Indeed a looser concept of a data paper has existed for some time, where researchers request a citation to a paper even though it is not the data nor fully describes the data (e.g the CRU temp records). Your ethics texts make it sound like you can snap your fingers and I will jump into your bed. also seem to misunderstand the data. are using the data to estimate the population frequency of identical twins rather than the state of this particular set of twins. The main strengths of this paper is that it addresses an interesting and timely question, finds a novel solution based on a carefully selected set of rules, and provides a clear answer. This could be the end of Michael Gove, or the moment he redefines Toryism forever, Aukus is the moment global Britain came alive, Parents of daughters cannot be expected to handle the nefarious power of Instagram alone, Why Harry ‘leaning in’ to Meghan isn’t the picture of equality he thinks it is, Gove is the man to square the circle between would-be home-owners and suburban Tory 'Nimbys', Britain faces a winter of economic carnage unless the Government gets its act together now. Upgrade to Inside PRO risk-free for 30 days. resolves this problem and allows fast and reliable INaL measurements. Even though the stimulus protocol was completely different the time courses for all the channels are highly correlated and 137 out of 196 correlations are significant. The linear equation can be put in Figure 3 caption (not necessary to include in text). Reserve “we” for reference to the authors and use something else (“a user” perhaps) for the other instances. Found insideSpiced with lots of information about the characters in HOLES, as well as lots of do's and don'ts for survival, this is an essential book for all those hundreds of thousands of HOLES' fans. We provide 24/7/365 editorial support, and can also provide translation services when required. It’s a solid enough fantasy novel, but typically male dominated with a token (romantic but tough) heroine. I have been neglecting this series (and author) for far too long, and after I read that prologue I was fiending for the actual story. The authors have clarified several of the questions I raised in my previous review. What is the role of the curator or data scientist in all of this? I was very pleased to see the within-isolate behavior was consistent in replicate experiments one year apart. That is a useful metaphor, but I think the ecosystem metaphor has broader acceptance. As a more minor point with regard to the data set and what the authors want it to do, there were some inconsistencies as to how the study was framed. The pruning result is arguably the most important one here – this suggests an intriguing trade-off between poaching and bird conservation (in particular, the suggestion that pruning by poachers may bolster Pipit populations – or at the very least mitigate against other aspects of habitat degradation). Found inside – Page 1759th. by no means does justice to a cedar canoo in his comparison. First, as to weight, I am now building from the Hob Roy model a canoe 14ft. long and ... 1. However, one possible way to analyse this example using frequentist methods would be to assess the likelihood of obtaining the data for each of the two hypothesis (the twins are identical or fraternal). Springer-Verlag, New York. They specifically focused on the hypothesis that sperm competition risk, arising from male mate choice copying, and avoidance of aggressive interactions play a key role in driving the evolution of audience-induced changes in male mate choice behavior. The third problem I see regards all the GLMs in which species are compared. The Labor Department has launched an overhaul of the technology that runs the unemployment insurance system, which was overwhelmed by claims … Average hits (correct prediction) for each stimulus was calculated across subjects. The parents-to-be ask Efron to tell them the probability that the twins are identical. reducing the open channel probability, while veratridine increases the number of channels in the burst mode. Please try again, Email address not valid, please try again. I like the choice of the term validation as more accurate than “quality” and it fits quite well with Callaghan’s useful distinction between technical and scientific review, but I think the authors overemphasize the peer-review style approach. This is further corroborated by the fact that when using stimulus labels that are chosen completely at random (i.e. If, instead, we set the prior as dbeta(1,2), which has a mean of 1/3, then the posterior probability that these twins are identical is 1/2. okay. One advantage of taxize is that it draws together a rich selection of data stores to query. Hence there was something in S. pombe that could feel the impact of this protein. An innovative open access publishing platform offering rapid publication and open peer review, whilst supporting data deposition and sharing. Hydbring and Badalian-Very summarize in this review, the current status in the potential development of clinical applications based on miRNAs’ biology. I think it contributes towards further alternatives to easily visualize high dimensionality data on the web. The authors tested the CytoPatch automated patch-clamp equipment and performed whole-cell recordings in HEK293 cells stably … Have we solved the basic problem and are now just dealing with edge cases? I believe this is an important paper to teach in intro graduate courses as it illustrates beautifully how important it is to know about and embrace the many new sources of systematic genetic information and apply them broadly. In this simulation, I assumed that all subjects contributed 20 trials, but in the actual data analyzed in the study, some subjects contributed fewer than 20 trials due to artifacts in the pupil measurements. Here, the awesome power of the model organism community comes into the picture as there is a zebrafish model of spinal muscular atrophy. Are they satisfied with the Lawrence et al. There are also some tantalizing hints in the Discussion that are not really discussed in the Findings ‐ of, for instance, the way in which communicator’s personal motivations may combine with their perceptions of audiences to shape their products. This will become increasingly relevant as the scope of taxize increases through the addition of new data stores that the package can access. The figure StimulusTimecourses.jpg in, The authors now acknowledge in their response that all the participants were authors. Related, in one location I noticed something amiss with the layout; in the first code block at the top of page 5, the printed output looks wrong here. Overall though, this is a timely and needed essay. Even though the developed classifiers seem to be more robust than previous such parameters, they remain only overall indications which can only allow statistical considerations. We’d love your help. Can this be resolved? Given the authors’s backgrounds, I was surprised this role was not emphasized more. Other than that there were the following minor observations: Hydbring and Badalian-Very summarize in this review, the current status in the potential development of clinical applications based on miRNAs’ biology. I should however state that it is laudable that the authors chose to make all the raw data of their experiment publicly available. Emma Raducanu is the stress-free sports star this country needs (and she doesn’t grunt!). The paper by Chevalier et al. 2002. This pair was exposed to a different stimulus paradigm (2 minutes of initial silence and a longer paradigm with three signal periods). Let us know what’s wrong with this preview of, Published Will the more basic solutions work in the interim? And I very much agree with a comment above - the character development trivialises a life of intense childhood trauma, betrayal and abandonment. WOAH. Indeed, when the assumption of common slopes is violated (as in It will be a book I recommend to others. In terms of presentation in the paper, I really don’t like the way the R code inputs merge with the R outputs. Finally, we wish to obtain Pr(x = 1 | y = 1), the probability the twins are identical given they are the same gender1. Even if your mum had died the previous week, you had lost your job and your husband had left you, you were always just fine. What would these people look like? Found insideEducating the Student Body makes recommendations about approaches for strengthening and improving programs and policies for physical activity and physical education in the school environment. Found inside – Page 352[ The best way , probably , would be to plow the whole other difficulty often is , that buyers , whether agents should let it be known ; there certainly ... Are We Training Pit Bulls To Review Our Manuscripts? For each subject the PD values across the 20 trials were converted to z-scores. [I was so fucking invested in Kelsier, his death completely broke me and my little black heart. As to the package, I am not overly fond of long function names; the authors should consider dropping the data source abbreviations from the function names in a future update/revision of the package. In point, they show that H1 is not just a nice little partner of nuclear DNA as previously thought. Based on all these factors, it is impossible for me to approve this manuscript. Without knowledge about Pr(x = 1), we might use Pr(x = 1) ~ dunif(0, 1), which is consistent with Laplace. This facet of the study opens for these investigators a new avenue they may wish to follow: the role of H1 in stimulation of neuroinflammation with overexpression of cytokines. Fundamental analytical flaws and weaknesses in the design should be ruled out first. Should the phylogenetic trees have some scale to them? I liked the characters, including a strong female heroine, Vin (her trust issues and ultimately her heroism), and the world-building that was there from beginning to end. A bit more detail about breeding sites as well as dispersal behavior etc. A further suggestion for a future update would be to add generic function names, that apply to a database connection/information object. Found inside – Page 2One should think of the Institute therefore not so much in a utilitarian ... and our problem is how to foster an intellectual approach which will carry ... The likelihood of the twins having the same gender under the hypothesis that they are fraternal is 0.5. are correct to point this out. Box 1 also implies Amrhein et al. There is no reason to assume it follows the same model as research literature publication. For each stimulus the total hits and misses were calculated. Found insideThe book expands on the foundation laid out in the 2000 report and takes an in-depth look at the constellation of influences that affect individual learning. Similarly, if all twins were identical (Pr(x = 1) = 1), then Pr(x = 1| y = 1) = 1. Efron suggests that Bayesian calculations should be checked with frequentist methods when priors are uncertain. It’s a solid e. It reads like an RPG - that was my thoughts - I had flashes of Lara Croft at random moments snd kept waiting for the trolls or similar. For this purpose, new classifiers had to be developed which were based on carefully curated data. The abstract is concise and accurately summarizes the essential information of the paper although it would be better if the authors define more precisely the anatomic specificity of valvulopathy – mild mitral regurgitation. Does it allow to a good voltage control even when generated currents are big and fast? It may be beyond the scope of this paper to fully examine incentive structures, but it at least needs to be acknowledged that building on the current model doesn’t seem to be working. I apologize in advance for this. They should also take care that the degrees of freedom are approximately equal to the number The addition of the considerable literature on news values to the mix makes the discussion more confusing again. They say that this is also acknowledged in the methods section, but I did not see any statement about that in the revised manuscript. Bierbach and co-authors investigated the topic of the evolution of the audience effect in live bearing fishes, by applying a comparative method. Based on the excessive Bayes Factor of 390,625 it is clear that the authors assumed a chance level of 50% on their binomial test. And I enjoyed what clearly has the potential to be a very rich data set. Found inside – Page 2Unfortunately, despite our efforts, Bulletin readers won't in this issue ... "Many of the Secretary's general views on security in Europe are already in the ... It … The report also examines the opportunities and challenges of altering the food supply-both at home and outside the home-and outlines lessons learned, best practices, and next steps. There are a number of questions left hanging: is the purpose to understand communicator experiences ‐ in which case why focus on perceptions of audiences? Argues that the foundation of success in business and personal pursuits is building trust, and outlines how to implement the eight pillars of trust in order to enjoy better relationships, reputations, and results. manuscript describes a beautiful synthesis of contemporary genetic approaches to, with astonishing efficiency, identify lead compounds for therapeutic approaches to a serious human disease. while not fully considering who is responsible for what. That was a crazy epic adventure full of fantastic characters and action packed madness! He's damn good' Nicholas Lezard, Guardian 'One of the best books about addiction and recovery to appear in recent memory' Sunday Times Somewhere in the not-so-distant future the residents of Ennet House, a Boston halfway house for ... The authors have made this data readily accessible in a downloadable spreadsheet. Pg 5, paragraph above Figure 1: You refer to converting the object to an **ape** *phylo* object and then repeat essentially the same information in the next sentence. I've seen an enormous number of opinions about Sanderson's books on the fantasy forums I hang out on, the great majority favourable. As a consequence these organisms are also more dependent on the protein folding machinery. and Ph.D., I am better educated than you, which gives me more power than you have with your Ph.D. As far as I can tell, I am much wealthier than you, which gives me another form of power over you. P. 8: discussion of classification of habitat types in ASF is certainly interesting, but could be made much more succinct in keeping with focus of this paper. I'm going to abandon my usual practice of writing short, pithy reviews and just drunkenly ramble on a few things here. Was Fisher’s z-transformation used, or were the data pooled across pairs? As such this article represents an excellent and elegant bioinformatics genome-wide study which will almost certainly influence our thinking about protein aggregation and evolution. The article is well written, treats an actual problem (the risk of development of valvulopathy after long-term cabergoline treatment in patients with macroprolactinoma) and provides evidence about the reversibility of valvular changes after timely discontinuation of DA treatment. I can't remember being this violently conflicted about a book in quite some time. correctly points out that the difference in the posterior probabilities is merely a consequence of mathematical logic. Found inside – Page 11Live stock , farming prices and extraordinary inducements in the implements ... Farm for Sale . again placed before our readers , and young should embrace ... I represent that one thing you've never been able to kill, no matter how hard you try. The authors demonstrated that the recording quality was so high that the automated device allows to the differentiation between noise and current, even when measuring currents of less than 5 pA of amplitude. Given this phenotype, the authors then went to work and using the power of the synthetic genetic array approach pioneered by Boone and colleagues made a systematic set of double mutants combining the human expressed UBA1 gene with knockout alleles of a plurality of S. pombe genes. The bone of contention in the Efron papers and the critique by Amrhein et al. Instead, Efron combines different pieces of expert knowledge from the doctor and genetics using Bayes’ theorem.”. As Christine Borgman suggests, we need to look more closely at who we are trying to incentivize to do what. I believe the importance of this paper stems from the applicability of the approach to the several thousand of rare human disease genes that Next-Gen sequencing will uncover in the next few years and the challenge we will have in figuring out the function of these genes and their resulting defects. Assuming I understand correctly (see point 3), random sampling one half of data samples from an EEG trace are. the last 20%. of species (not the number of trials). Considering that I used the, The authors argue in their response and the revision that predictive strategies were unlikely. INTERNATIONAL THRILLER WRITERS AWARD WINNER AND BARRY AWARD NOMINEE FOR BEST FIRST NOVEL • NAMED ONE OF THE BEST BOOKS OF THE YEAR BY BOOKPAGE The town of Henbane sits deep in the Ozark Mountains. (2003a) Bayes’ Theorem in the 21st Century.

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