Top of the page . Learn about bempedoic acid and the CLEAR program. [7], Following oral intake, bempedoic acid reaches highest blood plasma concentrations after 3.5 hours. [2] Of ESP15228, 99.2% are bound to plasma proteins. [2] Food does not affect its absorption. Davis Drug Guide PDF. For two statins, simvastatin and pravastatin, your doctor may change the dose if you also take NEXLETOL. Bempedoic acid, sold under the brand name Nexletol among others, is a medication for the treatment of hypercholesterolemia (high blood cholesterol levels). Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you … bempedoic acid 180mg and ezetimibe 10mg fixed-dose combination in patients with hypercholesterolemia and a high risk of cardiovascular disease receiving maximally tolerated statin therapy. bempedoic acid Pharmaco-therapeutic group (ATC Code): Lipid modifying agents, other lipid modifying agents (C10AX15) Therapeutic indication(s): Nilemdo is indicated in adults with primary hypercholesterolaemia (heterozygous familial and non-familial) or mixed dyslipidaemia, as an adjunct to diet: • in combination with a statin or statin with other lipid lowering therapies … BEMPEDOIC ACID N14 Page 1 of 1 92 . Hourra! [12] Bempedoic acid was approved for use in the European Union in April 2020,[3] and the combination bempedoic acid/ezetimibe was approved in March 2020. Félicitations! What is the most important information I should know about bempedoic acid? [2], Bempedoic acid has a biological half-life of 21±11 hours. (3)Department of Medicine. Bempedoic acid is first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor used once a day for reducing LDL cholesterol levels in statin-refractory patients. Tendon problems may be more likely in certain people (older adults, people with kidney disease, or people who take … It contains 180 mg of bempedoic acid. [5] The trial designs were similar. [13], In February 2020, bempedoic acid was approved for use in the United States. [2] Both bempedoic acid and the metabolite are inactivated by glucuronidation of their carboxylic acid groups. [4][14][15][16] The U.S. Food and Drug Administration (FDA) granted the approval of Nexletol to Esperion Therapeutics. Vous pouvez contribuer cette prononciation audio de bempedoic acid au dictionnaire HowToPronounce. Bempedoic acid may also be used for purposes not listed in this medication guide. [5] In both trials, subjects were randomly assigned to receive bempedoic acid or placebo tablets every day for 52-weeks. This medicine is authorised for use in the European Union. [2], Bempedoic acid does not interact with the cytochrome P450 enzyme system in the liver and only weakly inhibits the transporter proteins SLCO1B1, SLCO1B3 and SLC22A7 (the latter possibly being responsible for the increase of uric acid in the blood, and therefore the adverse effect gout). [2], In the EU, bempedoic acid is indicated in adults with primary hypercholesterolaemia (heterozygous familial and non familial) or mixed dyslipidaemia, as an adjunct to diet in combination with a statin or statin with other lipid-lowering therapies in patients unable to reach LDL C goals with the maximum tolerated dose of a statin; or alone or in combination with other lipid-lowering therapies in patients who are statin intolerant, or for whom a statin is contraindicated. It is not known if bempedoic acid can lower the risk of complications related to high cholesterol (such as heart problems, heart attack, stroke, or death). Overview; Authorisation details; Product information; Assessment history; Authorised. Tu as gagné {{app.voicePoint}} points. View All Manufacturers & Suppliers of Bempedoic Acid API with Drug Master Files (DMF), CEP/COS, Japanese DMFs, Written Confirmation (WC) details listed on PharmaCompass.com PURPOSE OF REVIEW: Bempedoic acid has emerged as a potent inhibitor of ATP … Bempedoic acid blocks an enzyme in the liver called adenosine … Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. This can happen within days or months after you start taking bempedoic acid. Bempedoic Acid / Eze Homemade Tia Maria Recipe,
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